This course aims to provide students with fundamental knowledge on the principles of biochemistry. In the beginning, the structures and functions of bio-macromolecules will be introduced. This is followed by mechanisms of enzymes, and the key metabolic pathways and their relevance to diseases. Basic concepts of gene expression, regulation and manipulation will be introduced to students, and they be exposed to common techniques used by molecular biologists, with special emphasis on the applications in medicine. The knowledge will be reinforced by practical sessions in BMSC1009.  Students’ learning will also be enhanced by group discussions and case studies.